Highlights •CBD is a beneficial immune regulator in TMEV-IDD model, with long-term effects. •CBD treatment improves motor deficits in the chronic phase of TMEV-IDD. •CBD decreases VCAM-1, CCL2/CCL5 chemokines and TNFα/IL-1β. •Adenosine A2A receptors mediate some of the CBD effects both in vivo and in...

A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis   The present study was designed to investigate the efficacy of a new formulation of alone, purified cannabidiol (CBD) (>98 %), the main non-psychotropic cannabinoid of Cannabis sativa, as a...

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