How CBD Oil Reduces Inflammation

Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs).

Cannabinoids such as CBD are generally free from the adverse effects associated with NSAIDs and can provide a new approach to treatment of acute and chronic inflammation and fibrosis.

Cannabinoids, inflammation, and fibrosis.
FASEB J. 2016 Jul 19. pii: fj.201600646R.


This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, cannabidiol.

Cannabinoids, endocannabinoids, and related analogs in inflammation.
AAPS J. 2009 Mar;11(1):109-19. doi: 10.1208/s12248-009-9084-5. Epub 2009 Feb 6.


Cannabidiol (CBD) has been shown to exert potent anti-inflammatory and antioxidant effects and has recently been reported to lower the incidence of diabetes in nonobese diabetic mice. CBD, which has recently been approved for the treatment of inflammation, pain, and spasticity associated with multiple sclerosis in humans, may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption.
Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H610-9. Epub 2007 Mar 23.


Cannabis is frequently used by patients with multiple sclerosis (MS) for muscle spasm and pain, and in an experimental model of MS low doses of cannabinoids alleviated tremor.

Cannabinoids in clinical practice.
Drugs. 2000 Dec;60(6):1303-14.


Nonpsychoactive cannabinoid-based drugs such as CBD Hemp Oil have been tested and found moderately effective in clinical trials of multiple sclerosis, traumatic brain injury, arthritis, and neuropathic pain.

Therapeutic potential of cannabinoid-based drugs.
Adv Exp Med Biol. 2007;601:395-413.


Cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance in rodents.

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
J Exp Med. 2012 Jun 4;209(6):1121-34. doi: 10.1084/jem.20120242. Epub 2012 May 14.


Acute lung injury is an inflammatory condition for which treatment is mainly supportive because effective therapies have not been developed. This study shows that CBD Oil has anti-inflammatory effects in a murine model of acute lung injury

Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor.
Eur J Pharmacol. 2012 Mar 5;678(1-3):78-85. doi: 10.1016/j.ejphar.2011.12.043. Epub 2012 Jan 12.


Hemp CBD Oil may protect against kidney damage resulting from the use of Cisplatin, a chemotherapy agent. Treatment of mice with cannabidiol improved renal function and reduced the oxidative stress, inflammation, and cell death in the kidney after being injected with Cisplatin.

Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death.
J Pharmacol Exp Ther. 2009 Mar;328(3):708-14. doi: 10.1124/jpet.108.147181. Epub 2008 Dec 12.


In this study CBD was observed to stimulate hippocampal neurogenesis, the process by which neurons are generated from neural stem cells and progenitor cells.

Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement.
PLoS One. 2011;6(12):e28668. doi: 10.1371/journal.pone.0028668. Epub 2011 Dec 5.


Diabetic retinopathy is a leading cause of blindness among working-age adults. Despite many years of research, treatment options for diabetic retinopathy remain limited and with adverse effects. This review is focused on the therapeutic effects of cannabidiol (CBD), a non-psychoactive native cannabinoid, as an emerging and novel therapeutic modality in ophthalmology.

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.
World J Diabetes. 2010 Mar 15;1(1):12-8. doi: 10.4239/wjd.v1.i1.12.


Results of this study indicate that CBD Oil unravels a new therapeutic strategy to treat inflammatory bowel diseases.

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.
PLoS One. 2011;6(12):e28159. doi: 10.1371/journal.pone.0028159. Epub 2011 Dec 6.



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