23 Jun What Happens If You Give Your Pet Too Much CBD?
One of the main reasons many people are turning to CBD oil for pets has been due to the reputation of how safe it is.
In fact, in 2017, the World Health Organization’s Expert Committee on Drug Dependence suggested that in addition to being “generally well tolerated with a good safety profile,” CBD had “no public health problems” when taken as a pure extract from the cannabis plant (including both hemp and marijuana varieties).
That being said, it is also known that ALL chemical substances are potentially lethal if taken in a high enough dose. Even water can be fatal to humans if too much is consumed within too short a time period.
Although there have been no reports showing that your pet can overdose on CBD by consuming it orally, the lethal levels for CBD administered intravenously has been listed by the federal government’s Toxicology Data Network.
How much CBD is fatal for my pet?
The short answer – it would take more CBD to be fatal for your pet than your pet could ever consume at once!
A more scientific answer can be determined from three different studies listed below that have been conducted over the past 70 years.
Established toxicity levels are known as an LD50. The LD50 (LD stands for “lethal dose”) of any given chemical compound is the amount that it would take to kill 50% of test subjects at a certain dose.
- In 1946, the LD50 for cannabidiol in dogs was determined to be greater than 254 mg per kg of body weight, when administered intravenously.
- In 1975, an LD50 was established in mice at 50mg per kg of body weight, when administered intravenously.
- In 1981, a report in Toxicology and Applied Pharmaocology show the LD50 for CBD to be 212 mg per kg of body weight when administered intravenously in monkeys.
More recently, a 2011 article in Current Drug Safety observed toxic levels of CBD in rhesus monkeys when administered orally. Doses over 200 mg per kg of body weight proved to be fatal in some monkeys by way of respiratory arrest and cardiac failure, while 300 mg per kg of body weight resulted in “rapid death.”
For reference, consider a relatively “average sized” canine at 19 kg (approx. 41lbs). By these numbers, it would take roughly 4,688 mg (4.68 g) of pure CBD consumed within a very short amount of time to result in any potentially fatal effects. By comparison, the average dose of CBD for pets is only 5mg-10mg of the compound — and that’s throughout the course of an entire day.
How do I know if I have given my pet too much CBD?
- Dry Mouth: Your dog can’t tell you if they have dry mouth, but it’s safe to say they might increase their water intake. And increased thirst could also be a sign of other serious problems, such as antifreeze or rodenticide poisoning, or conditions like diabetes.
- Tremors: Human patients with Parkinson’s disease have reported increased tremors at high doses of CBD. Tremors of any kind should be cause for concern in a dog.
- Lowered blood pressure: High doses of CBD have been known to cause a temporary drop in blood pressure. Even though the drop is small, it might create a brief feeling of light-headedness.
- Lightheadedness: Your dog won’t tell you if they’re feeling lightheaded, but they might seem disoriented or dizzy.
- Drowsiness: Pay attention to your dog’s sleeping patterns to see if there’s any change.
- CYP45 Enzymes: The one side effect of concern with high doses of CBD is its affinity to temporarily inhibit enzymes that metabolize drugs in the liver — grapefruit does this as well. If your pet is on a dosage-sensitive prescription drug that’s metabolized in the liver, you’ll likely want to keep CBD dosages lower and/or not dose at the same time as the other medication.
Your veterinarian will be able to help you monitor your pet to ensure that CBD’s relationship with the other drug is positive.
How Much CBD Should I give my pet?
Hemp CBD Dosage Guidelines:
- Low Dose: 0.022 mg/lb or 0.05mg/kg
- Medium Dose: 0.136 mg/lb or 0.30 mg/kg
- Strong Dose: 0.22 mg/lb or 0.5mg/kg
After a week, incrementally increase the dose with additional milligrams until you’ve achieved the desired effect for whatever is being treated. A good rule of thumb is increase the original dose amount by 2X (from 0.25 up to 0.50 mg’s per kg) after observing signs for 2-weeks.
For preventive health and aging, the low tier of 0.022 mg/lb or 0.05mg/kg is a great place to start. There’s may be days that you want to increase to the medium tier to help with situational issues like stress or allergies.